Activation of the septal region by direct injection of acetylcholine produced local electrical changes in two epileptic patients and a shift in mood from disphoria to contentment and euphoria, usually with concomitant sexual motivation and some "orgastic sensations.
http://www.wireheading.com/delgado/index.html
Also see: "The Orgasmic Brain" http://www.paradise-engineering.com/brain/
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